Sofia Botti

Sofia Botti

Postdoctoral Researcher
Euler Institute, Università della Svizzera Italiana
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Current and Previous Positions

01/2026 — present
Contract Researcher — Politecnico di Milano
Under FIS Starting Grant SYNERGIZE
11/2023 — 10/2025
Postdoctoral Researcher — Università della Svizzera Italiana
SNSF Postdoctoral Fellowship (PI) - Grant number: 217025
11/2022 — 10/2023
Postdoc Assistant — University of Pavia & Università della Svizzera Italiana
Joint position across Pavia and Lugano
Under H2020-EuroHPC Microcard project - Grant agreement ID: 955495.

Research Interests

Ionic models for hiPSC-CMs
Ionic models for hiPSC-CMs
Cardiac electrophysiology
Cardiac electrophysiology
Engineered heart tissue modeling
Engineered heart tissue modeling

Publications

Journal Articles

Article
In silico modelling of multi-electrode arrays for enhancing cardiac drug testing on hiPSC-CM heterogeneous tissues
S. Botti, R. Krause, L.F. Pavarino
Journal of Physiology, 2025 DOI PDF
Article
A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents
S. Botti, C. Bartolucci, C. Altomare, M. Paci, L. Barile, R. Krause, L.F. Pavarino, S. Severi
Computers in Biology and Medicine, 2024 DOI PDF
Article
Isogeometric simulation of a derived stem cell engineered ventricle
S. Botti, M. Torre
Advances in Computational Science and Engineering, 2023 DOI PDF

Conference Proceedings and Book Chapter

Article
Advanced Bidomain Framework for Drug Testing in Heterogeneous Cardiac hiPSC Tissues
S. Botti, R. Krause, L.F. Pavarino
Cardiovascular Modeling, in Springer INdAM series Accepted paper
Article
An in silico Study of Cardiac hiPSC Electronic Maturation by Dynamic Clamp
S. Botti, C. Bartolucci, R. Krause, L.F. Pavarino, S. Severi
Functional Imaging and Modeling of the Heart, 2023 DOI PDF
Article
Numerical Simulations Indicate IK1 Dynamic Clamp Can Unveil the Phenotype of Cardiomyocytes Derived from Induced Pluripotent Stem Cells
S. Botti, C. Bartolucci, C. Altomare, L. Barile, R. Krause, L.F. Pavarino, S. Severi
Computing in Cardiology, 2022 DOI PDF

Arxiv Preprints

Article
A novel ionic model for matured and paced atrial-like hiPSC-CMs integrating IKur and IKCa currents
S. Botti, C. Bartolucci, C. Altomare, L. Barile, R. Krause, L.F. Pavarino, S. Severi
bioRxiv preprint DOI PDF

PhD Thesis

Article
Mathematical modeling of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs): from ionic currents to 3D ventricle models
S. Botti DOI

Teaching Activities

Lecturer

  • 08/2025 – 01/2026 Algorithmics (BSc) FernUni-Unidistance, Brig, Switzerland
  • 06/2025 Modeling the electrophysiology of the cardiac tissue Ph.D. Summer School

    • Teaching Assistant

  • 10/2022 – 01/2023 Sistemi dinamici (MSc) Università degli Studi di Pavia
  • 10/2022 – 01/2023 Analisi 1 (BSc) Università degli Studi di Pavia
  • 10/2021 – 01/2022 Analisi 1 (BSc) Università degli Studi di Pavia
  • 12/2020 – 02/2021 Analisi 1 - Didactic seminars (BSc) Università degli Studi di Pavia
  • 11/2020 – 12/2020 Mathematics - Precourse Precours Università degli Studi di Pavia

Contacts

Location
Dipartimento di Matematica,
Via Bonardi 9,
20133 Milano (MI), Italy
Building 14 (“Nave”), fifth floor